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KMID : 0383820090670020145
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Tuberculosis and Respiratory Diseases
2009 Volume.67 No. 2 p.145 ~ p.147
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A Case of Anaphylaxis after the Treatment with Etoposide in a Patient with Small Cell Lung Cancer
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Kim Young-Il
Kim Kyu-Sik
Han Eui-Ryoung
Kwon Yong-Soo
Oh In-Jae
Lim Sung-Chul
Kim Young-Chul
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Abstract
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Etoposide is a semi-synthetic derivative of podophyllotoxin that is effective against many cancers including small cell lung cancer. We report a case of etoposide-induced anaphylaxis in a 51-year-old woman who tolerated etoposide during her first cycle chemotherapy regimen. During the second cycle, she complained of generalized urticaria and dyspnea 5 minutes after being infused with etoposide. She recovered completely with antihistamine, corticosteroid and fluid replacement. The intradermal skin test with etoposide showed a clear positive immediate reaction. This case suggests that etoposide can induce IgE-mediated anaphylaxis.
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KEYWORD
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Etoposide, Anaphylaxis, Small cell lung carcinoma, Skin tests
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